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Collectively, this ECM-related 7-gene signature provides a novel insight for survival prediction among GC patients. Silencing CTCF or COL1A1/COL1A3 markedly inhibited cell growth and migration in the metastatic GC cell line BGC823. Furthermore, CTCF regulated COL1A1 and COLA31 expression in vitro. A comparison of human GC cell lines with high or low expression of ECM-related genes revealed different levels of tumor aggressiveness, suggesting the cancer development-promoting functions of ECM-related genes. In addition, CTCF was also correlated with the Wnt signaling pathway. CTCF binding sites also overlapped with histone activation markers, indicating direct regulation. Interestingly, putative CCCTC-binding factor (CTCF) regulatory elements were identified within the promoters of these ECM-related genes and were confirmed by chromatin immunoprecipitation sequencing (ChIP-Seq).

We combined different gene expression datasets and filtered a 7-gene signature related to the extracellular matrix (ECM), which also exhibited significant prognostic value in GC patients. We aim to describe clinically relevant molecular classifications of GC that incorporate heterogeneity and provide useful clinical information.

Gastric cancer (GC), a leading cause of cancer-related death, is a heterogeneous disease. 4Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.3Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Hudson Institute of Medical Research, Clayton, VIC, Australia.2Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.1Faculty of Medical Laboratory Science, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.KFHC Enhanced Care Management Brochure ( English/Spanish).Chenbin Liu 1†, Linyi Deng 1†, Jinrong Lin 2, Jianjun Zhang 1, Shu Huang 1, Jinglin Zhao 1, Peipei Jin 1, Peiqing Xu 1, Peihua Ni 1, Dakang Xu 1*, Le Ying 1,3,4* and Yiqun Hu 1*.Department of Health Care Services Enhanced Care Management.There is no cost to the Member for ECM services. Coordination and Referral to Community and Social Support Services.A Comprehensive Assessment and Care Management Plan.Individuals enrolled in ECM will receive services including:

The ECM care team will work together with the individual’s health care providers including their doctors, specialists, pharmacists, case managers, and others, to coordinate the needed care and services.

Individuals receiving hospice services.ĮCM provides care coordination services lead by a care team.

Who is not eligible to receive ECM services?

Intellectual or developmental disability.

The individual transitioned from incarceration within the last 12 months and has at least one (1) of the following:.

Is pregnant or is less than 12 months post-partumĪdults who are transitioning from incarceration.

Had two (2) or more emergency department visits, or two (2) or more hospitalizations due to SMI or SUD in past 12 months.

Is at high risk of hospital or skilled nursing facility admission, overdose, and/or suicide.

Uses the emergency department, urgent care, or inpatient hospital as sole source of care.

The individual is receiving services through County Specialty Mental Health or Drug Medi-Cal and meets one (1) or more of the following:.

Imminently losing housing in next 30 daysĪdults who have been admitted to the hospital three (3) or more times in the past six (6) months or have visited the Emergency Department five (5) or more times in the past six (6) monthsĪdults experiencing a serious mental illness or suffering from a substance use disorder.

KFHC Members may qualify for ECM if they are within one (1) or more of the following Populations of Focus. You or the eligible KHFC Member may also be contacted by KHS or our contracted ECM providers to see if they are interested in enrolling into an ECM Program. If you would like more information or to find out the KFHC Member qualifies please call us at 1.800.391.2000. These services help coordinate the Member’s physical, behavioral, developmental, oral health, long term services and supports (LTSS), and services that address social determinants of health. Kern Health Systems (KHS) offers the Enhanced Care Management (ECM) benefit for eligible Kern Family Health Care (KFHC) Members. Important information about changes in your pharmacy benefit.Important public safety power shutoff information.Important Coronavirus (COVID-19) Information.